Outcome of Salt Substitution on Cardiovascular Occasions and Loss of life

Tom Smith

Summary Track record Salt substitutes with lowered sodium amounts and enhanced potassium amounts have been shown to lower blood strain, but their consequences on cardiovascular and security outcomes are unsure. Solutions We carried out an open-label, cluster-randomized demo involving individuals from 600 villages in rural China. The contributors experienced a […]

Summary

Track record

Salt substitutes with lowered sodium amounts and enhanced potassium amounts have been shown to lower blood strain, but their consequences on cardiovascular and security outcomes are unsure.

Solutions

We carried out an open-label, cluster-randomized demo involving individuals from 600 villages in rural China. The contributors experienced a background of stroke or had been 60 decades of age or older and experienced higher blood tension. The villages have been randomly assigned in a 1:1 ratio to the intervention group, in which the members employed a salt substitute (75% sodium chloride and 25% potassium chloride by mass), or to the manage team, in which the contributors continued to use standard salt (100% sodium chloride). The key end result was stroke, the secondary outcomes ended up major adverse cardiovascular functions and demise from any lead to, and the security outcome was medical hyperkalemia.

Effects

A complete of 20,995 individuals had been enrolled in the trial. The indicate age of the individuals was 65.4 years, and 49.5% ended up female, 72.6% had a background of stroke, and 88.4% a heritage of hypertension. The indicate period of stick to-up was 4.74 many years. The charge of stroke was decrease with the salt substitute than with normal salt (29.14 gatherings vs. 33.65 functions for every 1000 particular person-many years rate ratio, .86 95% self-assurance interval [CI], .77 to .96 P=.006), as were the charges of important cardiovascular occasions (49.09 activities vs. 56.29 functions for every 1000 human being-yrs rate ratio, .87 95% CI, .80 to .94 P<0.001) and death (39.28 events vs. 44.61 events per 1000 person-years rate ratio, 0.88 95% CI, 0.82 to 0.95 P<0.001). The rate of serious adverse events attributed to hyperkalemia was not significantly higher with the salt substitute than with regular salt (3.35 events vs. 3.30 events per 1000 person-years rate ratio, 1.04 95% CI, 0.80 to 1.37 P=0.76).

Conclusions

Among persons who had a history of stroke or were 60 years of age or older and had high blood pressure, the rates of stroke, major cardiovascular events, and death from any cause were lower with the salt substitute than with regular salt. (Funded by the National Health and Medical Research Council of Australia SSaSS ClinicalTrials.gov number, NCT02092090.)

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