Panisa Manasirisuk,1 Nanthaphan Chainirun,1,2 Somsak Tiamkao,2,3 Sunee Lertsinudom,4 Kutcharin Phunikhom,5 Bundit Sawunyavisuth,6 Kittisak Sawanyawisuth3
1Office of Pharmacy Provider, Srinagarind Hospital, College of Medication, Khon Kaen College, Khon Kaen, Thailand 2Built-in Epilepsy Exploration Group, Khon Kaen College, Khon Kaen, Thailand 3Division of Medication, College of Medicine, Khon Kaen College, Khon Kaen, Thailand 4Division of Pharmaceutical Treatment, College of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, Thailand 5Office of Pharmacology, Faculty of Drugs, Khon Kaen University, Khon Kaen, Thailand 6Office of Marketing and advertising, College of Business Administration and Accountancy, Khon Kaen University, Khon Kaen, Thailand
Correspondence: Nanthaphan Chainirun
Office of Pharmacy Service, Srinagarind Clinic, College of Medicine, Khon Kaen College, Khon Kaen, 40002, Thailand
Email [email protected]
Section of Medication, College of Medicine, Khon Kaen College, Khon Kaen, 40002, Thailand
Electronic mail [email protected]
History: The capability of statins to cut down LDL-c plays an important role in equally most important and secondary avoidance of atherosclerotic cardiovascular conditions. These types of therapy can usually be expensive, but making use of generic atorvastatin may perhaps decrease cost by up to US$2635. In addition, a previous 8-7 days research uncovered that it exhibited comparable efficacy to the brand-identify medication. This review aimed to evaluate the efficacy of generic atorvastatin more than a for a longer time time period of six months in a actual-planet environment.
Procedures: This was a retrospective cohort review in adult people who experienced gained manufacturer-name atorvastatin for at the very least a few months and then experienced switched to generic atorvastatin for at the very least 6 months. Lipid and safety profiles were being evaluated at 6 months right after switching. Altered analyses for age, intercourse, co-morbid illness, dosage, and indications for statin remedy were also done.
Final results: During the study time period, there were being 488 individuals who satisfied the study conditions. The indicate (SD) age of the people was 60.97 (12.26) years, and 48.36% have been male (236 clients). At six months, typical whole cholesterol, HDL-c, and LDL-c had been all decrease, from 174.43 to 166.15 mg/dL, from 51.64 to 49.51 mg/dL, and from 110.08 to 100.78 mg/dL (p < 0.001), respectively. There were no significant differences in terms of any other laboratory test results. LDL-c exhibited the highest significant reduction at 9.30 mg/dL. Stratified analyses by age, sex, co-morbid disease, dose, and indications for statin therapy revealed similar decreases in HDL-c and LDL-c as in the study population as a whole.
Conclusion: Generic atorvastatin resulted in significantly lower LDL-c than name-brand atorvastatin but less of an increase in HDL-c.
Keywords: low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, HMG CoA reductase inhibitors
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