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BMC Geriatr. 2021 Mar 3121(1):219. doi: 10.1186/s12877-021-02158-1.
History: Coronavirus illness 2019 (COVID-19) is a pandemic infection with substantial possibility of dying, specially in aged individuals. Information about the prognostic importance of useful position in more mature individuals with COVID-19 is scarce.
Procedures: Demographic, scientific, laboratory and limited-phrase mortality info were being collected of 186 consecutive clients aged ≥ 65 a long time hospitalized with COVID-19. The facts were being as opposed amongst 4 analyze groups: (1) age 65-79 many years with out critical purposeful dependency (2) age ≥ 80 decades without the need of significant useful dependency (3) age 65-79 decades with serious functional dependency and (4) age ≥ 80 years with extreme useful dependency. Multivariate logistic regressions were being done to appraise the variables that have been most noticeably connected with mortality in the entire sample.
Effects: Statistically significant variances were noticed in between the groups in the proportions of males (p = .007) of clients with diabetes mellitus (p = .025), cerebrovascular ailment (p < 0.001), renal failure (p = 0.003), dementia (p < 0.001), heart failure (p = 0.005), pressure sores (p < 0.001) and malignant disorders (p = 0.007) and of patients residing in nursing homes (p < 0.001). Compared to groups 1 (n = 69) and 2 (n = 28), patients in groups 3 (n = 32) and 4 (n = 57) presented with lower mean serum albumin levels on admission (p < 0.001), and were less often treated with convalescent plasma (p < 0.001), tocilizumab (p < 0.001) and remdesivir (p < 0.001). The overall mortality rate was 23.1 %. The mortality rate was higher in group 4 than in groups 1 – 3: 45.6 % vs. 8.7 %, 17.9% and 18.3 %, respectively (p < 0.001). On multivariate analysis, both age ≥ 80 years and severe functional dependency were among the variables most significantly associated with mortality in the entire cohort (odds ratio [OR] 4.83, 95 % confidence interval [CI] 1.88 – 12.40, p < 0.001 and OR 2.51, 95 % CI 1.02 – 6.15, p = 0.044, respectively). Age ≥ 80 years with severe functional dependency (group 4) remained one of the variables most significantly associated with mortality (OR 10.42, 95 % CI 3.27-33.24 and p < 0.001).
CONCLUSIONS: Among patients with COVID-19, the association of severe functional dependency with mortality is stronger among those aged ≥ 80 years than aged 65-79 years. Assessment of functional status may contribute to decision making for care of older inpatients with COVID-19.